To make the dough. Place yeast and sugar into a stand mixer with the dough hook attached. Add the warm water and gently stir. Let sit until yeast has doubled and is puffed and foamy on top, about 10 minutes.
To the bowl add the melted butter, warm milk, pumpkin puree and egg, stir to combine. Add in the flour and salt. Knead the dough with the dough hook until the dough is smooth and forms a ball, about 5 minutes. Remove the dough from the bowl and oil the bowl or use cooking spray. Place the dough back in the bowl and cover with plastic wrap. Let the dough rise in a warm area for about 1 hour or until doubled in size.
To make the filling. Add the sugar and cinnamon to a bowl and mix well. Generously grease a 9x13 inch baking dish, or slightly smaller baking dish, with butter.
Lightly dust a surface with flour. Roll the dough into a rectangle (about 9x24 inches). Spread about 6 tablespoons of the butter (softened almost to a melted phase) evenly over the dough. Spread the cinnamon sugar evenly over the butter and lightly push the cinnamon sugar into the butter.
Starting with the long edge closest to you, carefully roll the dough into a log, keeping it fairly tight as you go. When you reach the edge, pinch along the edge to seal. Place dental floss or a thin piece of string (do it!! it works so well!) under the roll where you want to cut. Mine are usually about 3/4 to 1 inch thick, but vary. Take the ends of the floss in each hand and wrap them around the roll. Keeping the ends of the floss in each hand (don’t let go) tighten the floss so it starts to cut through the roll. Again, don’t change hands. Tighten until the floss comes out and the individual roll is separated. You can make eight larger rolls OR 10-12 smaller rolls.
Place rolls in the prepared pan. Cover with a damp cloth or plastic wrap and allow to rise in a warm place until doubled in size, about 30 minutes.
Preheat the oven to 350. Just before baking brush the remaining 2 tablespoons of butter on top of the rolls. Bake the rolls for 25 minutes or until golden brown.
Meanwhile, make the frosting. Beat the cream cheese and butter together until light and fluffy. Slowly add the powdered sugar until combined. Add the vanilla bean seeds (or vanilla extract) and nutmeg, mix until smooth and creamy.
Spread the frosting on warm rolls. EAT!